Pharmacokinetics, Pharmacodynamics, and ADME Studies
Understanding pharmacokinetics (PK), pharmacodynamics (PD), and absorption, distribution, metabolism, and excretion (ADME) is critical for drug optimization. PK/PD studies determine dose-response relationships, therapeutic windows, and systemic exposure. ADME profiling ensures appropriate bioavailability, metabolic stability, and elimination, minimizing toxicity. Integration of modeling, simulation, and in vitro/in vivo studies supports rational dosing strategies and informs clinical trial design. Advanced analytical techniques, including mass spectrometry and bioinformatics, facilitate precise measurement of drug behavior. Comprehensive PK/PD and ADME analysis underpins the development of safe, effective, and personalized therapeutics.
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