Pharmacoclogy & Drug Discovery

Nanotechnology-Based Drug Delivery Systems

Nanotechnology-based drug delivery systems offer precision in targeting, controlled release, and enhanced bioavailability of therapeutics. Nanocarriers, including liposomes, polymeric nanoparticles, dendrimers, and metallic nanostructures, facilitate efficient transport of drugs to specific tissues, minimizing systemic toxicity and improving therapeutic indices. These delivery systems enable encapsulation of small molecules, biologics, nucleic acids, and imaging agents for diagnostic and therapeutic applications. Surface functionalization and ligand-targeted strategies enhance cellular uptake and specificity, particularly in oncology, infectious diseases, and neurodegenerative disorders. Controlled-release technologies allow sustained or stimuli-responsive drug delivery, optimizing pharmacokinetics and patient compliance. Advances in nanomedicine have also addressed challenges such as solubility, stability, and immune evasion, providing versatile platforms for complex therapeutics. Preclinical and clinical studies demonstrate improved efficacy, reduced adverse effects, and the potential for combination therapies using nanocarriers. As regulatory guidelines evolve, nanotechnology-based drug delivery continues to expand opportunities for precision medicine, targeted therapy, and innovation in pharmacological interventions, redefining treatment paradigms and improving patient outcomes globally.