Bhupendra G Prajapati
Ganpat University, India
Title: Intranasal voriconazole-loaded nanoemulsion for enhanced therapy of cryptococcal meningitis
Biography
Biography: Bhupendra G Prajapati
Abstract
Statement of the Problem: Cryptococcal meningitis is a fungal infection which mainly impacts the membrane enveloping the brain and spinal cord. Voriconazole is known to have promising therapeutic agent for treatment of fungal infection which is commercially available in both oral and intravenous administrations. In this study, the voriconazole-loaded nanoemulsion formation was developed with the aim to enhance the brain delivery via nasal administration for the treatment of cryptococcal meningitis.
Methodology and Theoretical Orientation: The selection of optimal composition of Oleic acid, Tween 80 and Transcutol P as oil phase, surfactant, and co-surfactant was performed using pseudo-ternary phase diagrams. The results of physicochemical characterization showed that the selected formulations exhibited small droplet size, low polydispersity, adequate zeta potential, etc.