Leni Herliani Afrianti
Universitas Pasundan, Indonesia
Title: Potent -Glucosidase, -Amylase, and -glucosidase Inhibitor Activity of Ethanol Extract,3-hydroxystigmastan-5(6)-en (terpenoid), and Pyrolle-2,4- dicarboxylic acid-methyl ester from Salacca edulis Reinw variety Bongkok for antidiabetic agent
Biography
Biography: Leni Herliani Afrianti
Abstract
The study was designed to evaluate the potential α-glucosidase, β-glucosidase, and α-amylase inhibitor activity of ethanol extract, 3-hydroxystigmastan-5(6)-en (terpenoid), and Pyrolle-2,4-dicarboxylic acid-methyl ester of the S.edulis for anti-diabetic agent.Type 2 diabetes mellitus (T2DM) or non-insulin dependent diabetes melitus are the most prevalent form of diabetes and tend to increase especially in the developing countries.Snake fruit, Salacca (Sallaca edulis reinw) variety. Bongkok is one of the tropical fruits that posses bioactivity. Two new compounds belong to pyrrole and terpenoid was found in the previous study. However the antidiabetic potential of ethanol extract and that two compound from S.edulis have not been well characterized.The inhibitor activity of α-glucosidase, β-glucosidase, and α-amylase was performed to test the antidiabetic potential of Salacca edulis ethanol extract and its pyrrole and terpenoid compounds. Ethanol extract, terpenoid and pyrrole from S.edulis have α-glucosidase inhibitory activity in a concentration dependent manner. Pyrrole and S.edulis ethanol extract was the most active in inhibiting β-glucosidase activity, however terpenoidwas the most active compound that inhibits α-amylase selectivity.
