Sherri A Smith,
Relay Therapeutics, USA
Biography
Sherri Smith is experienced in drug metabolism and pharmacokinetics (DMPK) of small molecules from discovery through clinical development in the pharmaceutical industry. Recent publication efforts have focused on explaining discrepancies in plasma protein binding values due to interference of plasticizers commonly used in blood collection bags, to highlight species, ontogeny, and disease state differences in expression of α-1-acid glycoprotein (AAG) and to provide examples where human PK of drugs have been impacted by preferential binding to AAG. The overall aim is to bring attention to the relevance of accurate measurement of fraction unbound for the prediction human PK and pharmacodynamics
Abstract
Abstract : Pharmacokinetic and pharmacodynamic considerations for drugs binding to alpha-1-acid glycoprotein