Scientific Program

Conference Series LLC Ltd invites all the participants across the globe to attend 37th World Congress on Pharmacology Amsterdam, Netherlands.

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Scientific Program Day 1

Day 1 :

  • Adverse Drug Reactions
Location: Webinar

Chair

Lizeth Vargas-Nuñez

Industrial University of Santander, Colombia

Session Introduction

Lizeth Vargas-Nuñez

Industrial University of Santander, Colombia

Title: An Experimental Rat Model For The Evaluation Of Levofloxacin-induced Nociceptive Alterations And Protective Alternatives
Biography:

Lizeth Vargas-Nuñez is a biologist currently pursuing a master’s degree in Basic Biomedical Sciences at the Industrial University of Santander. Building upon her undergraduate studies in biology, she is now immersed in the intricate world of pharmacology and neuroscience. Her research focuses on elucidating the mechanisms underlying levofloxacin- induced peripheral neuropathy in a Wistar rat model. By understanding these mechanisms, she aims to contribute to the development of strategies to mitigate or prevent this adverse drug reaction.

Abstract:

Fluoroquinolone antibiotics are widely used to treat infections of the urinary, respiratory, and gastrointestinal tracts. Despite their efficacy, these drugs have been associated with several clinically significant adverse effects, including tendinopathy and peripheral neuropathy. Levofloxacin, a fluoroquinolone, is particularly linked to a high incidence of peripheral neuropathy, characterized by numbness, pain, loss of reflexes, and hyperesthesia. Notably, the specific mechanisms underlying levofloxacin-induced peripheral neuropathy remain poorly understood. The purpose of this study is to evaluate levofloxacin-induced nociceptive alterations aiming to establish a preclinical Wistar rat model of peripheral neuropathy for testing protective strategies.
 

  • Pharmacology
Location: Webinar

Chair

Bimal Roy Krishna

Touro University, USA

Session Introduction

Bimal Roy Krishna

Touro University, USA

Title: Current guidelines for the management of asthma
Speaker
Biography:

Bimal Roy Krishna is currently Professor and Director of Pharmacology at the College of Osteopathic Medicine, Touro University in Nevada. He obtained a Bachelor of Science (First Class Honors) in Pharmacology and Physiology and a Doctor of Philosophy, Medicine (OB/GYN/Pharmacology) from Monash University in Australia. He also teaches for the Step 1 USMLE and COMLEX reviews for Kaplan Medical throughout the United States and in UAE, Europe, Saudi Arabia, India, Mexico and the Caribbean. He has been teaching online for Kaplan University for over 7 years. He has contributed to numerous publications and is a member of a number of organizations including Fellow-American College of Clinical Pharmacology. His research background is in maternal and neonatal pharmacology specifically looking at materno-fetal transfer utilizing the perfused human placental and cultured syncytiotrophoblast model. Complementary and Alternative medicine is another area of interest.

Abstract:

Asthma is considered to be primarily an inflammatory disorder with secondary bronchoconstriction. Patient manifestations usually are shortness of breath, wheezing, cough and chest tightness. The intensity may vary over time and become exacerbated with external factors that further irritate the airway.While bronchial hyperactivity and airway inflammation may likely be present they are not the only factors that determine diagnosis. Identification of external and other factors that exacerbate asthma is crucial and smoking is also a modifiable factor.High risk patients including geriatric and pediatric patients may require more aggressive treatment.The long term goals of management are to achieve long term symptomatic relief which may include the use of prophylactic agents. Management of asthma initially supported the use of a short acting bronchodilator and prophylactic management where deemed necessary.The categories of asthma medications include controller, reliever, prophylactic and add-on medications.

Beom Su Jang

Korea Institute of Science and Technology, South Korea

Title: RI-ADME study design of C-14 radiolabelled amoxicillin depletion in industrial animal using accelerator mass spectrometry
Speaker
Biography:

Beom Su Jang has his expertise in evaluation of pharmacokinetic property of noble drug using radioisotope and nuclear imaging. Byeong yong Yoo has his expertise in application of accelerator mass spectrometry. They develop the new RI-ADME evaluation approaches based on accelerator mass spectrometry creates more powerful tools for improving C-14 analysis. They have built this model after years of experience in research, evaluation. The IAEA Coordinated Research Project (CRP): D52043.Depletion of Veterinary Pharmaceuticals and Radiometric Analysis of their Residues in Animal Matrices’ support this study.

Abstract:

The presence of veterinary pharmaceutical residue in animal matrices for food is a major concern from a public health. Such hazards (residues) must be regulated through establishment of national or internationally acceptable regulatory standards and guidelines. Maximum residue limits (MRL): the maximum concentration of residue resulting from use of a veterinary drug that is acceptable in a food is well established as an international guideline, Currently accelerator mass spectrometry is well established with the highest sensitivity for the analyze of C-14 in the samples. Meanwhile recent evidence indicates that humans constantly exposed the antibiotics from livestock; however, whether these contaminants pose a substantial risk to human health is far from understood. The lack of crucial data on exposure and hazard repꠓresents key knowledge gaps that need to be addressed to move forward. Regulation is necessary and to establish internationally acceptable standards/guidelines, scientificaly reliable data from depletion studies and associated analytical methods are required.

For the development of amoxicillin-depletion study, we propose a RI-ADME study using accelerator mass spectrometry for the assessment of the long half life radioisotopes such as C-14/H-3.

Also we propose the nuclear imaging using SPECT for gamma emmiting radioisotopes and PET uses radiotracers that produce positrons. These advenced RI-ADME procedures could applied for the biologics more easily.

  • Neuro Pharmacology
Location: Webinar

Chair

Bhupendra G Prajapati

Ganpat University, India