37th World Congress on Pharmacology
Amsterdam, Netherlands
Lizeth Vargas-Nuñez
Industrial University of Santander, Colombia
Title: An Experimental Rat Model For The Evaluation Of Levofloxacin-induced Nociceptive Alterations And Protective Alternatives
Biography
Biography: Lizeth Vargas-Nuñez
Abstract
Fluoroquinolone antibiotics are widely used to treat infections of the urinary, respiratory, and gastrointestinal tracts. Despite their efficacy, these drugs have been associated with several clinically significant adverse effects, including tendinopathy and peripheral neuropathy. Levofloxacin, a fluoroquinolone, is particularly linked to a high incidence of peripheral neuropathy, characterized by numbness, pain, loss of reflexes, and hyperesthesia. Notably, the specific mechanisms underlying levofloxacin-induced peripheral neuropathy remain poorly understood. The purpose of this study is to evaluate levofloxacin-induced nociceptive alterations aiming to establish a preclinical Wistar rat model of peripheral neuropathy for testing protective strategies.