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Shirley Taniguchi

Shirley Taniguchi

University of São Paulo, Brazil

Title: Pharmacological advice for clinical practice

Biography

Biography: Shirley Taniguchi

Abstract

Statement of the Problem: Treating drugs symptomatically, reversing drug side effects without considering the receptors involved, and combining drugs without following specific criteria, may result in inefficient attempts to resolve clinical events.

 

Administering depressant drugs to contain akathisia caused by neuroleptics may result in a significant reduction of consciousness levels. Treating immediate postoperative period opioid hallucinations with typical neuroleptics may cause motor agitation that could significantly affect the surgical procedure.

Treating L-Dopa hallucinations with neuroleptics may cause motor side effects contributing to the motor difficulties associated with Parkinson's disease.

Treating confusion with neuroleptics may increase the motor side effects associated with the use of central acting anticholinesterase inhibitors or cholinergic agonists in patients with Alzheimer's disease.

Findings: Difficult to control bleeding may occur with the administration of cardiotonic agents (phosphodiesterase inhibitors) in patients submitted to surgery.

Combining anticoagulants with drugs with a high albumin binding rate may also cause significant bleeding.

Methodology & Theoretical Orientation: This was a retrospective survey of patients hospitalized in a large general hospital located in the city of São Paulo (Brazil) and individual patients treated at several hospitals in the region.

 

 

 

 

 
  Text Box: Intravenous administration of voltage-dependent sodium channel

blockers such as phenytoin without accompanying cardiac function may

Text Box: lead to arrhythmia and difficult to reverse cardiac arrest.

 

 

 

 

 

 

 

 

 

 

Conclusion & Significance: An individualized medical prescription should contain drugs selected based on their mechanism of action, half life, albumin binding rate, and predicted side effects. This would help reduce risks and increase the chances of therapeutic success.