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Galina S. Mal

Kursk State Medical University, Russia

Title: Forming statin response in patients with coronary heart disease in presence of acute respiratory viral infections by means of genetic markers

Biography

Biography: Galina S. Mal

Abstract

Statement of the Problem: Development of CHD associated with atherosclerosis. One of the main pathogenetic causes of atherosclerosis development is inflammation, being an important atherogenesis component. Any acute infection may be the etiological factor which activates chronic inflammation in the atherosclerotic plaque, involving the cytokine system. A number of studies demonstrate the relation between an increase of cytokine level and the signs of atherosclerosis destabilization and CHD. The purpose of this study is to describe the drug response variability in CHD patients with an acute viral infection. Methodology & Theoretical Orientation: The study involved 170 CHD patients, 120 of whom also had infections (ARVI). The LDL-C and cholesterol levels were determined in the blood serum using an enzymatic method. Genotyping of polymorphisms IL-1β –511C>T, IL-6 –174G>C, IL-4 –589C>T, IL-10 –1082G>А was performed using a PCR method on the CFX96 Bio-Rad Laboratories amplifier (USA). Findings: Carriership of –511TT genotype were diagnosed with the lowest LDL-C level and a high HDL-C level (p<0.05), which confirmed the hypolipidemic statin effect. Carriers of –511СС genotype had the increased LDL-C levels. Carriership homozygous –1082GG genotype demonstrated the association with the level of Cholesterol (P=0.003). When the anti-inflammatory cytokine (IL-4, IL-10) level increased, C level decreased (P<0.05). The analysis of correlation between pro- /anti-inflammatory cytokine gene genotypes revealed the activity of genotypes –511TT (IL-1β gene), –174CC (IL-6 gene), –589TT (IL-4 gene), and –1082GG (IL-10 gene) in maintaining chronic inflammation stability (P=0.012).

Conclusion & Significance: The obtained correlations contributed to the preparation of personalized HLP pharmacotherapy algorithm in CHD patients in presence of ARVI. The presence of heterozygous –511CT genotype for –511C>T polymorphism of the IL-1β gene, homozygous –174GG genotype for –174G>C polymorphism of the IL-6 gene, and homozygous –1082AA genotype for polymorphism –1082G>A of the IL-10 gene did not lead to reaching the target LDL-C level.