Samuel P.B.Drawbridge
BVetMed MRCVS, UK
Title: Finding a medical solution to calcium oxalate urolithiasis: Which agents have the best dissolution potential? An integrative review
Biography
Biography: Samuel P.B.Drawbridge
Abstract
Calcium urolithiasis is a disease of major concern given its high prevalence, welfare and economic implications, and complications associated with current treatment and prevention strategies. A large number of publications were evaluated in this review to determine chemicals most evidential of calcium oxalate dissolution potential, the most prevalent stone component. The relevant literature was sourced through a keyword search of several online databases, and studies included if they showed evidence of an agent exhibiting dissolution activity upon calcium oxalate powder, crystals or stones. A critical analysis of these chemicals was undertaken, to determine those most efficacious, whilst also considering safety of medical use. This evaluation revealed citrates to be the most promising candidates for future research, given in vivo and in vitro data. Other factors influencing dissolution were also considered, including the ability of the immune system to dissolve calcium oxalate crystals.