Savita D Patil
H. R. Patel Institute of Pharmaceutical Education and Research, India
Title: Anti-arthritic activity of marketed lauha bhasma
Biography
Biography: Savita D Patil
Abstract
Ayurveda is the system of medicine which first recognized the importance of metals and minerals for curing ailments. Lauha bhasma is a one of the mineral based ayurvedic medicine mentioned in ayurvedic classics indicated for sotha (inflammation) and sula (pain). Current study planned to provide scientific support to such folk claims. In current study marketed lauha bhasma was characterized using modern analytical techniques like SEM, EDAX and XRD. Pharmacological assessment of lauha bhasma at three different doses was carried out in Freund's Complete Adjuvant (FCA) induced arthritis administered at 0.1 ml dose in hind paw of rats which was evaluated by various parameters such as paw volume at 7,14, 21, 28 day, hematological (RBC, WBC, HB, ESR count), CRP and RF levels. On 28 day, rats were sacrificed & histopathology was done. We found that treatment with all three doses of lauha bhasma alters various hematological parameters, CRP and RF levels compared to control group. Even this alteration has also seen at histopathological studies. These alterations significantly found to be highest at increasing doses of selected bhasma. Thus, our results justifies folk claim about lauha bhasma as an anti-inflammatory drug.