Pharmacology

Biography

Biography: T.G. Borovskaya

Abstract

Studies of the last decade show a degradation of reproductive health of men. At the same time great attention is paid to oxidative stress as a factor that negatively affects the organs of reproduction. The purpose of this work is to evaluate the effectiveness of antioxidants from the group of 8-hydroxy-pyridine, flavonoids, sterically hindered phenols in experimental models of pathospermia and benign prostatic hyperplasia (BPH). The experiments were performed on Wistar rats. Pathospermia was induced by a single administration of the cytostatic drug Etoposide in the maximum tolerated dose. BPH was induced by long-time administration (during 2 months) of Sulpiride. The both models gave a significant decrease in the redox potential, which is estimated by chemiluminescence. In the case of pathospermia was the only antioxidant from the group of sterically hindered phenols was found to be effective. This redox-potential of the male germ cells was not different from that of intact animals. The model of BPH showed statistically significant decrease of the area of epithelial acini under the introduction of all the studied antioxidants. But significant increase of the stromal-epithelial rate was found only on the background of the antioxidants from the group of hindered phenols. Redox-potential of prostate in this group of animals did not differ from the baseline values.