Sujit Nair
Amrita Vishwa Vidyapeetham University,India
Title: Pharmacometrics in the Translational Pharmacology Paradigm
Biography
Biography: Sujit Nair
Abstract
Exciting synergy between disciplines of pharmacokinetics, pharmacodynamics, pharmacogenomics, biostatistics and clinical pharmacology has translated into increased reliance on modeling and simulation strategies for better informing ‘go/no-go’ decisions, candidate optimization and biomarker validation in the discovery pipeline in pharmaceutical industry. With increasing practice of pharmacometrics in both the drug development and regulatory domains, we are moving away from empirical descriptions of exposure-response relationships towards more sophisticated pharmacometric models which we will exemplify and dissect. Strengths of model-based drug development and potential oversights will be discussed. With pharmacometrics fast occupying centre-stage in the translational medicine paradigm, unmet needs in modeling and simulation as well as future implications for personalized medicine will also be discussed.