Vladimir S. Naumenko
Institute of Cytology and Genetics, Russia
Title: Neurotrophic factors in the regulation of behavior
Biography
Biography: Vladimir S. Naumenko
Abstract
Among large family of the neurotrophines involved in the growth and survival of neurons the brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) attract particular attention due to their role in the behavioral control. This talk will summarize the data on the involvement of brain neurotrophic factors in the control of normal and pathological behavior. It will provide evidence on the implication of BDNF in epigenetically and genetically defined behavior in different animal models. Particularly, the talk will be focused on the BDNF effects on i) prenatal ethanol and stress exposure-induced behavioral disorders; ii) depressive-like behavior; iii) genetically determined aggressive behavior. It will also provide some data on the BDNF and GDNF role in the regulation of sensorimotor gating deficiency as well as GDNF involvement in the mechanisms of depression and learning. The cross-relation between neurotrophines and brain serotonergic and dopaminergic systems will be discussed
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