34^th World Congress on Pharmacology August 16-17, 2021 London, UK

Biography:

Marco Milanese is Associate Professor at the Department of Pharmacy of the University of Genoa. The scientific interest of Milanese Marco focuses on various aspects of neurotransmission and the molecular mechanisms involved in neurodegenerative processes; the research activity of Milanese Marco is characterised by the study of glutamatergic neurotransmission linked to excitotoxicity in neurodegenerative diseases, with particular interest to amyotrophic lateral sclerosis (ALS). The current research lines of Marco Milanese are aimed at studying the etiopathological mechanisms of ALS and develop translational strategies, by exploiting in-vivo behavioural analyses on experimental mouse models of ALS as well as functional in-vitro studies on motoneuron, astrocyte and microglia primary cell cultures. In this framework, very recently, Milanese Marco demonstrated the pivotal role of Group I mGluR receptors supporting the progression of ALS pathology. This research topic might pave the way for new therapeutic approach to counteract MN degeneration and ALS course.

Marco Milanese is Associate Professor at the Department of Pharmacy of the University of Genoa. The scientific interest of Milanese Marco focuses on various aspects of neurotransmission and the molecular mechanisms involved in neurodegenerative processes; the research activity of Milanese Marco is characterised by the study of glutamatergic neurotransmission linked to excitotoxicity in neurodegenerative diseases, with particular interest to amyotrophic lateral sclerosis (ALS). The current research lines of Marco Milanese are aimed at studying the etiopathological mechanisms of ALS and develop translational strategies, by exploiting in-vivo behavioural analyses on experimental mouse models of ALS as well as functional in-vitro studies on motoneuron, astrocyte and microglia primary cell cultures. In this framework, very recently, Milanese Marco demonstrated the pivotal role of Group I mGluR receptors supporting the progression of ALS pathology. This research topic might pave the way for new therapeutic approach to counteract MN degeneration and ALS course.

 

Abstract:

 

Amyotrophic lateral sclerosis (ALS) is fatal neurodegenerative disease characterized by a progressive degeneration of motor neurons (MNs). The etiology is still largely obscure, and several mechanisms have been proposed, including glutamate-mediated excitotoxicity. In this context, group I metabotropic glutamate receptors (mGluR1/5) play an active role, since their expression and functions are altered during the progression of the disease.

Behavioral, histological, and functional experiments have been performed to characterize the effects of mgluR5 modulation in both in-vivo and in-vitro ALS models. We investigated the effect of a partial or total genetic ablation of mGlu5 receptor in the SOD1G93A mouse model of ALS. We tested in-vivo the pharmacological blockade of mGluR5 by the negative allosteric modulator CTEP. Finally, we studied the effects of mGluR5 genetic or pharmacological modulation, on spinal cord astrocytes isolated from SOD1G93A mice.

Biography:

Ravi P. Sahu has expertise in various cancer models and related methodologies. His studies were among the ones to define the mechanistic insights of various anti- cancer agents, including naturally occurring phytochemicals in cancer chemoprevention. He has given several invited lectures in various scientific meetings, and has published over 60 peer-reviewed 60 articles in various scientific journals

Abstract:

Statement of the Problem: Naturally occurring dietary phytochemicals have gained significant attention due to their notable beneficial properties, including anti-inflammatory and antioxidant activities. For ages, dietary phytochemicals have been practiced to treat various health- related ailments due to their safe and non-deleterious effects. Importantly, in the past several decades, their anti-carcinogenic effects have been extensively explored against various highly aggressive malignancies, including triple-negative breast cancer (TNBC). Methodology & Theoretical Orientation: TNBC unlike other human malignancies, lacks definite prognostic markers. Besides, while improved survival responses have been documented with the ongoing therapeutic approaches, the development of tumor resistance mechanisms as well as serious adverse effects to these treatment options pose major challenges in the treatment of TNBC. Thus, rational combination strategies should be exploited as an alternative approach for effective treatment and/or management of TNBC. Findings, Conclusion & Significance: Among various dietary compounds, withaferin-A (WA), a phytochemical derived from an ayurvedic medicinal plant, Withania somnifera has been characterized to possess anti-inflammatory and anti-cancer properties against multiple tumor types, including TNBC using various in-vitro and in-vivo models. The overall goal is to highlight the mechanistic insights with recent updates, including the pharmacokinetics parameters of WA against breast cancer with major emphasis on TNBC.

Biography:

She is a midwifery research assistant and a lecturer in Health Science Faculty at Ege University. Also, she is a pre-perinatal massage therapist. She has science of master degree about antenatal education at Midwifery Department also doctorate degree about prenatal massage therapy at Women Health and Diseases Nursing Department. Yeliz works in academia for 16 years after working in the clinic for 2 years and conducts qualitative methodology. Midwifery education, pregnancy massage, culture, women's health, women studies, gender, domestic male violence to women and professional midwifery organization are the fields of her academic study. She has been a researcher in many national and international academic studies and projects. Yeliz is a Founding Board Member in 2014 of Association for Education, Research and Development in Midwifery (AERDM). Also, she is a member of Turkish Midwives Association and Anatolia Midwives Association. She is married and has two children.

Abstract:

The review aims to give some information about pre-perinatal massage and its importance for pregnant women and fetuses.

It is widely well-known that the nourishing touch provides an enjoyable experience for mothers and babies while improving health outcomes for mothers, babies, and also their families. However, evidence-based studies show that pre-perinatal massage therapy delivered by a nurturing touch benefits pregnant women and their babies. Studies show that massage therapy applied in the pre-perinatal period has positive effects on pregnant women and their babies; reduction of anxiety and/or depression, improvement of mood, reduced anger, better sleep quality, waist, back and/or leg less pain, more positive birth experience, more positive birth perception and less pain in labor, reduced fatigue, increased comfort, decreased stress hormones, less prenatal distress and more prenatal attachment, reduction of physiological lower leg edema, fewer complications during labor, better neonatal outcomes (less prematurity and low birth weight, better adaptation and motor response), a healthier immune system in babies and mothers.