Pharmacokinetics and Pharmacodynamics

Pharmacodynamics is the effect that drugs have on the body; while pharmacokinetics is the study of the way in which drugs move through the body during absorption, distribution, metabolism and excretion. Pharmacokinetics influences decisions over the route of administration. For drugs to produce their effects they must interact with the body. This can happen in many ways and depends on the properties of the drug, and will be discussed later in this chapter. Pharmacokinetics influences decisions over the route of administration. The processes that occur after drug administration can be broken down into four distinct areas (known as ADME):

  • Absorption of the drug
  • D Distribution of the drug molecules
  • Metabolism of the parent drug
  • E Excretion or elimination of the drug and its metabolites

  • Pharmacokinetic models
  • Bioavailability
  • Clinical pharmacokinetics
  • Population pharmacokinetics
  • Multicellular pharmacodynamics
  • Toxicodynamics

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