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P Naveen

Anurag Group of Institutions, India

Title: Neuroprotective activity of mucoadhesive microspheres of Nevirapine on cerebral ischemic stroke in Wistar rats

Biography

Biography: P Naveen

Abstract

Objective: To evaluate the neuroprotective effect of mucoadhesive microspheres of Nevirapine on cerebral ischemic stroke by middle cerebral artery occlusion in Wistar rats.

 

Method: Evaluation of Nevirapine mucoadhesive microspheres by particle size, morphology, drug entrapment efficiency, in vitro wash off test, in vitro drug release and interaction studies include Fourier Transfer Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC). The rats were pre and post treated with mucoadhesive microspheres of Nevirapine at selective doses (5, 10 mg/ kg/g, p.o) for a period of 14 days for evaluation of neuroprotective property in Middle Cerebral Artery Occlusion (MCAO) induced cerebral ischemic rats. Neurobehavioral changes were evaluated by using Y maze and open field habituation. Biochemical markers such as Acetyl Cholinesterase (AChE), glutamate, Differential Leukocyte Count (DLC), Lactate Dehydrogenase (LDH), antioxidants such as Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and catalase were estimated.

 

Results: Optimized formulation of Nevirapine mucoadhesive microspheres provided controlled delivery and prolonged residence at the absorption site. Obtain results revealed that 14 days of treatment with Nevirapine microspheres was effective forefend ischemia induced neurotoxicity. Nevirapine microspheres treatment decreases AChE, glutamate, DLC, LDH and increases the antioxidant parameters such as SOD, catalase and GPx.