D S Mohale
PRIST University, India
Title: Amelioration of altered blood glucose level by improving acetate and serotonin level of brain in immobilized stressed rat
Biography
Biography: D S Mohale
Abstract
Objective: The current study was designed to determine the effect of acetate and Selective Serotonin Reuptake Inhibitors (SSRI) on stress and blood glucose level in stressed rat.
Method: Animals were divided in 5 groups (n=6) , treated with 20 mg/kg p.o. of Fluoxetine (SSRI) and Glyceryl Triacetate (GTA) at 6 g/kg p.o dose (acetate supplementation) alone and in combination for 28 days to assess its effect in immobilized stressed rats. Open field and hole-board test were used for determination of stress in animals followed by blood glucose level.
Results: Animals treated with 20 mg/kg p.o Fluoxetine (SSRI), 6 g/kg p.o GTA and SSRI (Fluoxetine) + GTA showed significant (p<0.01) stress resistant activity as compared to negative control. Results also demonstrated that there was significant (p<0.01) decrease in blood glucose level in animals treated with 20 mg/kg p.o Fluoxetine (SSRI), 6 g/kg p.o GTA and SSRI (Fluoxetine) + GTA.
Conclusion: It concludes acetate and SSRI supplementation posse’s stress resistant and hypoglycemic potential in immobilized stressed rats by enhancing the acetylation of histone.