Elham Bidram
University of Isfahan, Iran
Title: Targeted graphene oxide networks as a novel cancer treatment
Biography
Biography: Elham Bidram
Abstract
An effective strategy to inhibit endocytosis in tumor cells is presented. The results suggest that the binding connects neighboring receptors, neutralizes endocytosis and causes metabolic deprivation. As a result, tumor cell survival and proliferation are reduced. Live cell confocal microscopy imaging reveals that the cellular interaction of these modified networks depended on the surface chemistry. In vitro exposure of tumor cells to this system reduces the cell viability by 35% compared to a 50% reduction using methotrexate (100 μM). The combination of the modified networks with Methotrexate (MTX) or Doxorubicin (DOX) shows a greater toxicity (80% reduction in cell viability) than the individual agents. The proposed setup demonstrates a significant synergy in limiting tumor cell growth.