Pharmacology and Toxicology

The purpose of this study is to promote awareness concerning increased incidence of colorectal cancer in younger population and its clinical plus pathological features compared to older patients. This cross-sectional study was conducted from January 2017 to October 2017 on patients with diagnosis of colorectal carcinoma admitted through emergency or outpatient departments to surgical wards of PIMS Hospital, Islamabad. Data concerning age, gender, presentation, site of tumor, surgery performed and TNM staging was used for analysis. Total numbers of patients studied were 27. Males were 17 (63%) and females were 10 (37%). Patients between the ages of 10 to 20 were 4, (15%), out of these patients 2 were declared unfit for surgery because of wide spread tumor within the abdomen as well distant metastasis. There were 9 (33%) patients between the ages of 21 to 30 and among these 4 was inoperable because of widespread disease. Patients between the ages of 31 to 40 were 5 (19%), 2 were inoperable, while cases between the ages of 41 to 50 were 4 (15%). There were 3 (11%) patients between the ages of 51 and 60 and 2 (7%) cases were between the ages of 61 to 70 years. Total 8 (30%) patients were inoperable and they were young patients, therefore colorectal carcinoma is more aggressive in young patients and 18 (82%) patients between the ages of 10 to 50 years had left sided disease.