Day 1 :
Keynote Forum
Debomita Sengupta,
Chittaranjan National Cancer Institute (CNCI), India
Keynote: Assessing the possibilities and risks associated with aurora kinase a targeting drug in breast cancer
Time : 11:10-11:50
Biography:
Debomita Sengupta has been working on breast cancer signaling pathways, diagnostics and treatment aspects for 15 years. Apart from her contributions in the reputed international journals in form of articles, reviews and book chapters, she has been a recipient of multiple prestigious research fellowships from the University Grants Commission, Department of Science and Technology and the Council of Scientific and Industrial Research, Govt. of India. Her PhD work was selected for presentation in the late-breaking category of the Annual Meeting of AACR; her postdoctoral work was selected for presentation in ESMO and honorary flash talk in Society of Biological Chemists, Kolkata. In addition to her work at CNCI, she is currently a member reviewer of the international journals like the Cellular Oncology, BMC Bioinformatics, Journal of Ovarian Research, Current Pharmacology Reports and American Journal of Translational Medicine.
Abstract:
Given the overexpression of Aurora Kinase A (AURKA) in 94% of breast cancer cases, AURKA-inhibitors have been tested without any betterment in response compared to conventional chemotherapeutic regimen proving that AURKA expression is dispensable during dissemination of breast cancer stem cells (BCSCs). In our study, we have observed AURKA upregulation by Oct4/Sox2 indicating that BCSCs may be targeted through AURKA in the cells undergoing active cell-cycle. However, the quiescent BCSCs without AURKA expression were found to circulate in patient blood irrespective of chemotherapeutic regimen demonstrating lack of the proliferative phase as an escaping route against chemotherapeutic regimen or AURKA-targeted therapies.
Keynote Forum
Bimal Roy Krishna
Touro University Nevada, USA
Keynote: Updated clinical indications of immunomodulators: Role in SARS-CoV-2
Time : 11:50-12:30
Biography:
Bimal Roy Krishna currently holds the position of Professor and Director of Pharmacology and Chair-SPC at the College of Osteopathic Medicine-Touro University Nevada. He has been Adjunct Professor of Pharmacology for Kaplan Medical for the past 12 years where he has been actively involved in Step-1 USMLE and COMLEX reviews throughout the USA and in Mexico, Caribbean, Poland, India, UAE, South America and Saudi Arabia. In addition he is an Adjunct and Visiting Professor at various other national and international institutions.
Abstract:
Immunomodulators have shown great promise in regard to prevention and treatment of various disorders ranging from autoimmune, inflammation, rheumatoid arthritis, Crohn’s Disease and infectious diseases. The global pandemic of 2020 related to SARS-CoV-2 or Coronavirus, saw the protective role of immunomodulators in reducing disease severity and in improving recovery.
- Pharmacology
Location: Webinar
Session Introduction
Raghad Alkanani
King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia
Title: Efficacy of omega-3 supplementation in olfactory dysfunction: A systematic review of randomized controlled trials
Biography:
Raghad Alkanani is a 5th year medical student and an aspiring researcher. She is very passionate about scientific research and public health. She has participated in more than 10 health awareness campaigns. Although she started conducting research only two years ago, she is currently working on 16 research projects and is willing to do more.
Abstract:
Background: Omega-3 supplementation has shown promising results in the treatment of Olfactory Dysfunction (OD). This systematic review assessed the effects of omega-3 supplementation on OD.
Methodology: A systematic literature search of Medline, Scopus, the Directory of Open Access Journals (DOAJ) and Google Scholar was conducted. Studies eligible for inclusion were Randomized Controlled Trials (RCTs) that included patients with OD whether received omega-3 or did not. The primary outcome measure was omega-3 effectiveness in improving olfactory dysfunction symptoms.
Ephrem Tesfay
Addis Ababa University, Ethiopia
Title: Does use of statins aggravate glycemic control in patients with type 2 diabetes: A retrospective cohort study
Biography:
Ephrem Tesfay is a Clinical Pharmacist at Addis Ababa University Tikur Anbesa Specialized Hospital. He holds a BPharm degree from Mekelle University and is currently pursuing his master's degree in Clinical Pharmacy. He has experience in providing pharmaceutical services in various healthcare settings, research and development, clinical practice, consulting and health system management. His research interests include medication safety and clinical pharmacy research and rational drug use. He is passionate about making sure that patients receive safe and effective pharmacological care in collaboration with medical care providers to ensure patient health outcomes. He is a member of Ethiopian Pharmaceutical Association.
Abstract:
Objective: The main purpose of the study was to assess glycemic control among statin users versus non-users in type 2 diabetes patients for a nine-year follow-up period.
Method: A retrospective cohort study was used on 204 study subjects in Tikur Anbesa Specialized Hospital. Medical records of eligible patients were followed from January 1st, 2011 until the occurrence of the outcome, date of administrative censoring or April 24, 2019.
Reem T. Attia
Future university in Egypt, Egypt
Title: The power of team based learning in pharmacology education. Uniting teams for enhanced learning
Biography:
Reem T. Attia, PhD, is an enthusiastic pharmacologist, researcher and lecturer. Her research is mainly focused on the pharmacological effect of newly synthesized anticancer drugs, In addition to the effect of nutraceuticals on the alleviation of diseases such as obesity and diabetes. Moreover, she likes to study the effect of anti-inflammatory medications and to develop methods of prevention of their side-effects on the patients. Finally, she is so passionate about the new interactive methods of education and she experiment with various educational tactics in her classroom.
Abstract:
Team-based learning (TBL) is a cutting-edge teaching strategy for the healthcare industry. It is distinguished by being an interactive learning environment that enables groups of students to collaborate in teams to debate and apply what they have learned to specific clinical scenarios. The purpose of the subsequent study is to assess how the TBL technique affects students' comprehension and information acquisition, to facilitate improved knowledge application and integration. The study's objective was to enhance pharmacy students' abilities to meet learning objectives by implementing TBL pedagogy in the lectures. Post-lecture surveys were used to gather feedback from the students.
Reem T. Attia
Future University in Egypt, Egypt
Title: Alpha boswellic acid alleviates the effect of irritants causing gastric ulcer disease in ethanol induced ulcer model in mice
Biography:
Reem T. Attia, PhD, is an enthusiastic pharmacologist, researcher and lecturer. Her research is mainly focused on the pharmacological effect of newly synthesized anticancer drugs, In addition to the effect of nutraceuticals on the alleviation of diseases such as obesity and diabetes. Moreover, she likes to study the effect of anti-inflammatory medications and to develop methods of prevention of their side-effects on the patients. Finally, she is so passionate about the new interactive methods of education and she experiment with various educational tactics in her classroom.
Abstract:
Gastric ulcer, also known as a peptic ulcer, is a prevalent gastrointestinal condition worldwide. It is characterized by the formation of open sores or ulcers on the lining of the stomach. Gastric ulcers can be caused by various factors, including infection with the bacterium Helicobacter pylori, long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), excessive alcohol consumption and stress. Globally, the prevalence of gastric ulcers varies across different regions and populations. According to the World Gastroenterology Organization, peptic ulcer disease affects approximately 10% of the world's population at some point in their lives. The incidence and prevalence of gastric ulcers have shown some variations in different countries and regions.
Mimansa Kandhwal
Chitkara University, India
Title: Drug repurposing approaches for depression: Rationale and its clinical experience
Biography:
Mimansa is currently pursuing her PhD from Chitkara University. She completed her high school from DAV Public School Safidon. She has her keen interest in Pharmacology and Neurological disorders. She is currently working on depression in her PhD. She has also got JRF (junior research fellowship) in DPSRU for a tenure of one year.
Abstract:
Drug discovery is a very time consuming, tedious and expensive process lasting for about two or more decades. This complexity of the process of drug discovery and sluggish pace at which new drugs are being discovered draw the attention of scientists to redefine the whole process with the help of drug repurposing. Usage of old drug moieties in any other disorder with all new mechanism is defined as repurposing. Repurposing of drugs knocks out the pre-clinical phase and related studies in order to give that molecule a redefined purpose. Data from these studies may be used in discovering newer molecules in order to save human effort, time and expenses as well.
Biography:
Ode Okwoche Julius is a Professor of Veterinary Pharmacology in the Department of Veterinary Pharmacology and Toxicology, University of Abuja, Nigeria. He specialized in the field of Drug discovery and Ethnopharmacology. He holds a PhD from the University of Nigeria, Nsukka and is a member of the College of Veterinary Surgeons, Nigeria (FCVSN). He has over 14 years of experience in teaching and conducting research within the University system. His current research is on drug discovery from natural products and toxicity of bioactive compounds. His has 56 research publications in per-reviewed journals. He collaborates with researchers in the Departments of Immunology and also Pathology, University of Manitoba, Canada.
Abstract:
African trypanosomosis, a neglected tropical disease of economic and health importance in man and animals is caused by diverse species of the protozoan parasite, Trypanosome. Although anti-trypanosomal medications exist, the lack of vaccines, increase in drug resistance and persistent antigenic variation in the parasites provoke the need to explore for potent agents with selective toxicity to the parasite. Trypanosoma congolense is the specie of concern because billions of dollars are lost per year due to its infection. Crosspteryx febrifuga is a popular herbal plant in Nigeria known to be effective in the treatment of several disease conditions. However, the anti-trypanosomal activities of this plant had not been investigated.