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Ke-He Ruan

Ke-He Ruan

Director
Center for Experimental Therapeutics and Pharmacoinformatics (CETP)
USA

Biography

Will be updated soon

Research Interest

Signaling Molecules and Drugs: Eicosanoids, Non-steroidal anti-inflammatory drugs (NSAIDs), targeting eicosanoid-biosynthesizing drugs, targeting eicosanoid-signaling drugs. Therapeutics Development for Diseases: Using small compounds/peptide/protein/gene/cells to develop novel approaches targeting Vascular Diseases (such as stroke and heart diseases), cancers and tissue regenerations. Drug targets: G Protein coupling receptors, P450 enzymes, eicosanoid-synthesizing enzymes, eicosanoid receptors Molecular Mechanisms: Eicosanoid Biosynthesis and Signaling in thrombosis, ischemia, cancers and stem cells. Biomedical field: Protein engineering, peptide synthesis, drug designs, membrane proteins, NMR structural biology. Approaches: Molecular cloning, protein/cell engineering, cell engineering, animal models, NMR spectroscopy, high throughput screening, virtual screening, computational chemistry. Assay Development: Automation robotic system for High throughput drug screening, virtual drug designs and screening, integration of experimental and virtual approaches in drug designs and screening.