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13th World Congress on Pharmacology and Toxicology, will be organized around the theme “Accelerations and Decelerations in Drug Discovery ”

Pharmacology Congress 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Pharmacology Congress 2018

Submit your abstract to any of the mentioned tracks.

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Pharmacology  is the study of how substances interact with living organisms to produce a change in function. It deals with the research, discovery, and characterization of chemicals which show biological effects and the illumination of cellular and organism function in relation to these chemicals. If substances have medicinal properties, they are considered pharmaceuticals. The Pharmacology encompasses mechanisms of drug action, drug composition and properties, interactions, toxicology, therapies, medical applications, and anti-pathogenic capabilities.

  • Track 1-1Scope
  • Track 1-2Medicine development and safety testing
  • Track 1-3Drug legislation and safety
  • Track 1-4Reverse pharmacology

Toxicology is the scientific study of adverse effects that occur in living organisms due to chemicals. It involves observing and reporting symptoms, mechanisms, detection and treatments of toxic substances, in particular relation to the poisoning of humans. It includes environmental agents and chemical compounds found in nature, as well as pharmaceutical compounds that are synthesized for medical use by humans. These substances may produce toxic effects in living organisms including disturbance in growth patterns, discomfort, disease and death. LD50 is a common term used in toxicology, which refers to the dose of a substance that displays toxicity in that it kills 50% of a test population. In scientific research, rats or other surrogates are usually used to determine toxicity and the data are extrapolated to use by humans.

  • Track 2-1Emergent Contaminants
  • Track 2-2Regulatory toxicology
  • Track 2-3Toxicokinetics
  • Track 2-4Toxicologic Pathology
  • Track 2-5Plant toxicology

Clinical Pharmacology has been practiced for centuries through observing the effects of herbal remedies and early drugs on humans. The pharmacologic effect that a medication has on the body is known as pharmacodynamics. Pharmacokinetic and pharmacodynamics parameters become important because of the association between host drug concentrations, microorganism eradication, and resistance. Since long scientific advances allowed scientists to come together with the study of physiological effects with biological effects Receptor theory for drug effects and its discovery with clinical pharmacology has stretched out to be a multidisciplinary field and has contributed to the findings of drug interaction, therapeutic effectiveness and safety. Drug interactions and pharmacological compatibilities include the study of pharmacokinetics that includes the absorption, distribution, metabolism, and elimination of drugs. The pharmacologic effect that a medication has on the body is known as pharmacodynamics. Pharmacokinetic and pharmacodynamics parameters become especially important because of the association between drug application, microorganism abolition, and resistance.

  • Track 3-1Drug interactions and pharmacological compatibilities
  • Track 3-2Receptor theory for drug effects
  • Track 3-3Clinical efficacy and safety evaluation
  • Track 3-4Novel options for the pharmacological treatment of chronic diseases

Psychopharmacology is the learning of the effects of medication on the psyche (psychology), observing changed behaviours and how molecular events are manifest in a measurable behavioural form. Neuropharmacology is the study of the effects of medication on central and peripheral nervous system performance. Principles related to psychopharmacology.  Neurogenesis and repair deal with other aspects on the indications for medications prescribed to address psychiatric and behavioural problems, that are associated with, including antipsychotic, anxiolytic and anticonvulsant medications, acquired brain injury and Neurocognitive effects associated with therapeutic drugs also include mood stabilizers and treatments prescribed for disorders of attention. The treatments may cause side effects such as induction of the metabolic syndrome, type-2 diabetes related to the medications prescribed for management of psychiatric and behavioural disorders and disturbances. Ethno psychopharmacology also deals with the biotransformation and metabolism of medications, as well as specific differential actions: i.e., CYP450 enzymatic inhibition and induction of metabolism of psychopharmacological and herbaceutical substrates.

  • Track 4-1Neuro signaling and its pathways
  • Track 4-2Neurogenesis and repair
  • Track 4-3Neuro Immune pharmacology and its associated diseases
  • Track 4-4Neurocognitive effects associated with therapeutic drugs
  • Track 4-5Dose response relation in psychiatric medications
  • Track 4-6Effect of androgenic anabolic steroids on psychosis
  • Track 4-7Networked Multicellular Pharmacodynamics

Pharmacodynamics is the effect that drugs have on the body; while pharmacokinetics is the study of the way in which drugs move through the body during absorption, distribution, metabolism and excretion. Pharmacokinetics influences decisions over the route of administration. For drugs to produce their effects they must interact with the body. This can happen in many ways and depends on the properties of the drug, and will be discussed later in this chapter. Pharmacokinetics influences decisions over the route of administration. The processes that occur after drug administration can be broken down into four distinct areas (known as ADME):

  • Absorption of the drug
  • D Distribution of the drug molecules
  • Metabolism of the parent drug
  • E Excretion or elimination of the drug and its metabolites
  • Track 5-1Pharmacokinetic models
  • Track 5-2Bioavailability
  • Track 5-3Clinical pharmacokinetics
  • Track 5-4Population pharmacokinetics
  • Track 5-5Multicellular pharmacodynamics
  • Track 5-6Toxicodynamics

Cardio pharmacodynamics of digitalis is most frequently used to increase the adequacy of the circulation in patients with CCF and to slow the ventricular rate in patients with atrial fibrillation or flutter NB: the main action of digitalis is its ability to increase myocardial contractility its positive isotropic action results in, a. increased cardiac output, b. decreased heart size, c. decreased venous pressure, d. decreased circulating blood volume. e. neural tissue being responsible for indirect cardiac actions of the drug finally, changes to the circulation brought about by digitalis frequently result in reflex autonomic & hormonal changes which effect the CVS. Role of drugs in coronary circulation the circulatory system is busy providing oxygen and nourishment to every cell of the body, let's not forget that the heart, which works hardest of all, needs nourishment. Ethnopharmacology is to identify the objectives of a largely virtual field whose self-identified membership represents a diverse suite of academic and applied disciplines, as well as commercial interests. Integrative Pharmacological Investigations include conglomeration of more number of pharmacological aspects and aggregated scientific research of two or more drugs. Natural products of chemistry in drug discovery play a vital role in bringing advances in traditional drug treatments. Chemistry and structural elucidation of drugs accelerate potential treatment options in the evolving developmental changes. Natural and synthetic derivatives in pharmacological studies are important aspect of advances in the development and investigation that avoid adverse drug reactions of the synthetic medicine. Mere change in the structures of the drugs can cause potential differences in efficacy and therapeutics of drug treatment.

  • Track 6-1Role of drugs in coronary circulation
  • Track 6-2Heart Diseases and failure
  • Track 6-3Interventional cardiology
  • Track 6-4Cardiotoxicity

Recent advances in DNA repair are DNA interstrand cross-links (ICLs) are lesions caused by a variety of endogenous metabolites, ecological exposures, and cancer chemotherapeutic agents that have two reactive groups. The general feature of these diverse lesions is that two nucleotides on opposite strands are joined covalently. Mutagenicity and carcinogenicity are clearly correlated. The somatic mutation theory of cancer holds that these agents cause cancer by causing the mutation of somatic cells. A unique feature of inter-strand cross-links repair is that both strands of DNA must be incised to completely remove the lesion. Drug dosing guidelines accomplished in sequential steps to prevent creating multiple double-strand breaks. Understanding the specificity of mutagens in bacteria has led to the direct implication of certain environmental mutagens in the causation of human cancers.

  • Track 7-1Cancer pharmcogenetics
  • Track 7-2Pharmacognosy
  • Track 7-3Pharmacology of drugs affecting vascular tone and blood pressure
  • Track 7-4Pharmacology of the Vascular endothelium
  • Track 7-5Recent advances in variant-disease pairs
  • Track 7-6Drug dosing guidelines
  • Track 7-7Mutagenecity- its implications in cancer following chemotherapy
  • Track 7-8Pharamcogenetic approach involved in modulating cell processes
  • Track 7-9Recent advances in DNA repair
  • Track 7-10Methods To determine biological targeting

Reverse pharmacology includes drug screening deals with reverse pharmacology and forward pharmacology are two approaches to drug discovery. Target based drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology, screening of chemical libraries and its pharmacology, methods to determine biological targeting, by systematically perturbing and interrogating biological pathways with synthetically novel chemical tools, preclinical validation of target biology is beginning to illuminate a more cost effective and efficient paradigm for the development of novel drugs modulating novel targets.

  • Track 8-1Reverse pharmacology
  • Track 8-2Target based drug discovery
  • Track 8-3Screening of chemical libraries and its pharmacology
  • Track 8-4Classical pharmacology
  • Track 8-5Biotransformation of chemicals
  • Track 8-6Food and chemical toxicology
  • Track 8-7Food safety and toxicology
  • Track 8-8Food and cosmetic toxicology

Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxic kinetics (including toxic kinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. Human toxicology studies address the mechanisms/modes of toxicity that deals with the safety evaluation of novel chemical, biotechnologically-derived products, and nanomaterials for human health assessment including statistical and mechanism-based approaches. Novel methods or approaches to research on animal and human tissues (medical and veterinary patients) investigating functional, biochemical and structural disorder.

  • Track 9-1Biological markers
  • Track 9-2Biomagnification
  • Track 9-3Acute poisonings in pregnancy
  • Track 9-4Laboratory diagnosis of poisonings

Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques. Furthermore new areas such as safety evaluation of novel foods and biotechnologically derived products and inter-relationships between nutrition and toxicology are welcomed. The studies may address the physiological, biochemical or pathological changes induced by specific substances, techniques for assessing potential toxicity, including molecular biology or the mechanisms underlying toxic phenomena.

  • Track 10-1Molecular toxicology
  • Track 10-2Biochemical toxicology
  • Track 10-3Food and chemical toxicology
  • Track 10-4Food safety and toxicology
  • Track 10-5Food and cosmetic toxicology

Genetic toxicology helps discern the possibility of heritable mutations, developmental defects, cancer initiation, aging and other long-term adverse genetic effects. Genotoxicity describes the assets of chemical sellers that damage the genetic records inside cellular causing mutations, which may lead to most cancers. At the same time, genotoxicity is often stressed with mutagenicity; all mutagens are genotoxic, while no longer all genotoxic materials are mutagenic. The alteration could have direct or indirect consequences at the DNA: the induction of mutations, mistimed occasion activation, and direct DNA damage leading to mutations.

  • Track 11-1Genotoxic Chemotherapy
  • Track 11-2Bacterial Reverse Mutation Assay
  • Track 11-3In vitro Toxicology Testing
  • Track 11-4Comet Assay

Ethnopharmacology is a study or comparison of the traditional medicine practiced by various ethnic groups, and especially by indigenous peoples. The word ethnomedicine is sometimes used as a synonym for traditional medicine. Ethnomedical research is interdisciplinary; in its study of traditional medicines, it applies the methods of ethnobotany and medical anthropology. Often, the medicine traditions it studies are preserved only by oral tradition.

Scientific ethnomedical studies constitute either anthropological research or drug discovery research. Anthropological studies examine the cultural perception and context of a traditional medicine. The purpose of drug discovery research is to identify and develop a marketable pharmaceutical product.

  • Clinical ethnopharmacy
  • Ethnopharmaceutics
  • Track 12-1Latest Trends in Ethnopharmacology
  • Track 12-2Phytochemical Studies of Plants and Plant Extracts
  • Track 12-3Advancements in Ayurveda and Unani
  • Track 12-4Natural Products in Clinical Pharmacology